Kao TI, Chen PJ, Wang YH, Tseng HH, Chang SH, Wu TS, Yang SH, Lee YT, Hwang TL*. Bletinib ameliorates neutrophilic inflammation and lung injury by inhibiting Src family kinase phosphorylation and activity. Br J Pharmacol. 2021 Oct;178(20):4069-4084.
Tsai YF, Chen CY, Lin IW, Leu YL, Yang SC, Syu YT, Chen PJ, Hwang TL*. Imperatorin Alleviates Psoriasiform Dermatitis by Blocking Neutrophil Respiratory Burst, Adhesion, and Chemotaxis Through Selective Phosphodiesterase 4 Inhibition. Antioxid Redox Signal. 2021 Oct 10;35(11):885-903.
Korinek M, Hsieh PS, Chen YL, Hsieh PW, Chang SH, Wu YH, Hwang TL*. Randialic acid B and tomentosolic acid block formyl peptide receptor 1 in human neutrophils and attenuate psoriasis-like inflammation in vivo. Biochem Pharmacol. 2021 Aug;190:114596.
Wu YH, Kuo CF, Hsieh AH, Hsieh HL, Chan YF, Hwang TL*. Upregulation of miR-210–5p impairs dead cell clearance by macrophages through the inhibition of Sp1-and HSCARG-dependent NADPH oxidase pathway. Free Radic Biol Med. 2021 Jun 29;172:441-450.
Lin YJ, Wei KC, Chen PY, Lim M*, Hwang TL*. Roles of neutrophils in glioma and brain metastases. Front Immunol. 2021 Aug 13;12:701383. (Review)
Chiang CC, Cheng WJ, Korinek M, Hwang TL*. Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus Disease. Front Pharmacol. 2020 Oct 9;11:572009. (Review)
Yang SC, Tsai YF, Pan YL, Hwang TL*. Understanding the role of neutrophils in acute respiratory distress syndrome. Biomed J. 2020 Sep 10:S2319-4170(20)30149-9. (Review)
Lu YJ, Wang YH, Sahu RS, Chen JP, Dash BS, Chung PJ, Yang HW, Chuang EY*, Hwang TL*. Mechanism of Nanoformulated Graphene Oxide-Mediated Human Neutrophil Activation. ACS Appl Mater Interfaces. 2020 Sep 9;12(36):40141-40152.
Yang SC, Wang YH, Tsai YF, Chang YW, Wu TS, Ho CM, Hwang TL*. A Synthesized Heterocyclic Chalcone Inhibits Neutrophilic Inflammation Through K+-Dependent pH Regulation. FASEB J. 2020 May;34(5):7127-7143.
Chiang CC, Cheng WJ, Lin CY, Lai KH, Ju SC, Lee C, Yang SH, Hwang TL*. Kan-Lu-Hsiao-Tu-Tan, a Traditional Chinese Medicine Formula, Inhibits Human Neutrophil Activation and Ameliorates Imiquimod-Induced Psoriasis-Like Skin Inflammation. J Ethnopharmacol. 2020 Jan 10;246:112246.
Chen PJ, Ko IL, Lee CL, Hu HC, Chang FR, Wu YC, Leu YL, Wu CC, Lin CY, Pan CY, Tsai YF, Hwang TL*. Targeting allosteric site of AKT by 5,7-dimethoxy-1,4-phenanthrenequinone suppresses neutrophilic inflammation. EBioMedicine. 2019 Feb;40:528-540.
Liu FC, Yu HP, Chen PJ, Yang HW, Chang SH, Tzeng CC, Cheng WJ, Chen YR, Chen YL*, Hwang TL*. A novel NOX2 inhibitor attenuates human neutrophil oxidative stress and ameliorates inflammatory arthritis in mice. Redox Biol. 2019 Jul 10;26:101273.
Tsai YF, Chen CY, Chang WY, Syu YT, Hwang TL*. Resveratrol suppresses neutrophil activation via inhibition of Src family kinases to attenuate lung injury. Free Radic Biol Med. 2019 Dec;145:67-77.
Chen CY, Lee YH, Chang SH, Tsai YF, Fang JY*, Hwang TL*. Oleic acid-loaded nanostructured lipid carrier inhibit neutrophil activities in the presence of albumin and alleviates skin inflammation. Int J Nanomedicine. 2019 Aug 16;14:6539-6553.
Chiang CC, Cheng WJ, Korinek M, Lin CY, Hwang TL*. Neutrophils in Psoriasis. Front Immunol. 2019 Oct 9;10:2376. (Review)
Kuo LM, Chen PJ, Sung PJ, Chang YC, Ho CT, Wu YH, Hwang TL*. The bioactive extract of pinnigorgia sp. induces apoptosis of hepatic stellate cells via ROS-ERK/JNK-caspase-3 signaling. Mar Drugs. 2018 Jan;16(1). pii: E19.
Yang SC, Chen PJ, Chang SH, Weng YT, Chang FR, Chang KY, Chen CY, Kao TI, Hwang TL*. Luteolin attenuates neutrophilic oxidative stress and inflammatory arthritis by inhibiting Raf1 activity. Biochem Pharmacol. 2018 Jun 6;154:384-96.
Yang SC, Chang SH, Hsieh PW, Huang YT, Ho CM, Tsai YF, Hwang TL*. Dipeptide HCH6-1 inhibits neutrophil activation and protects against acute lung injury by blocking FPR1. Free Radic Biol Med. 2017 Feb 21;106:254-69.
Tsai YF, Chu TC, Chang WY, Wu YC, Chang FR, Yang SC, Wu TY, Hsu YM, Chen CY, Chang SH, Hwang TL*. 6-Hydroxy-5,7-dimethoxy-flavone suppresses the neutrophil respiratory burst via selective PDE4 inhibition to ameliorate acute lung injury. Free Radic Biol Med. 2017 Mar 3;106:379-92.
Pei-Wen Hsieh, Tsong-Long Hwang, Wen-Hui Wang, Ting-Yi Wang. Oxime-based compound, pharmaceutical composition containing the same and method for preparing the same. US 9,073,833 B1; Date of patent: Jul. 7, 2015.
Tsong-Long Hwang, Pei-Wen Hsieh, Yin-Ting Huang, Chih-Hao Hung. FPR1 antagonist derivatives and use thereof. US 9,593,144 B2; Date of patent: Mar. 14, 2017.
Tsong-Long Hwang, Yeh-Long Chen, Cherng-Chyi Tzeng, Chih-Hua Tseng. Neutrophil inflammation inhibitor and uses thereof. US 10,654,848 B1; Date of patent: May 19, 2020.